Population
Chimeric mice made of homozygous Ang II receptor type 1A gene null mutant cells and Agtr1a intact cells…
Comparison
Angiotensin II infusion for 2 weeks vs Control chimeric mice made of wild-type cells…
Design
Preclinical
Follow-up
2 weeks
Authors
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Myocyte-fibroblast Ang II communication drives remodeling in mice; leaves open whether cardiomyocyte Agtr1a targeting alters human HF.
This study demonstrates that Angiotensin II-dependent cardiac remodeling and fibroblast proliferation rely on local communication from neighboring cardiomyocytes possessing intact Ang II receptors.
Matsusaka et al. (1999) studied this question.
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