Key result
Angiotensin II acted as a mitogen in sham-operated and non-infarct rat cardiac myofibroblasts and stimulated hypertrophy in infarct myofibroblasts.
Angiotensin II exerts differential regional effects on cardiac myofibroblasts post-myocardial infarction, promoting proliferation in non-infarcted tissue and hypertrophy in the infarct scar.
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Differential Ang II effects on post-MI myofibroblasts remain preclinical; extends remodeling models but leaves open human translation.
Staufenberger et al. (2001) studied Acute myocardial infarction. Angiotensin II vs. Sham operated and non-infarct myofibroblasts was evaluated on Cell number, cell area, total protein, and AT(1) receptor mRNA. Angiotensin II acted as a mitogen in sham-operated and non-infarct rat cardiac myofibroblasts and stimulated hypertrophy in infarct myofibroblasts.
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