Key result
Species variability in ANG II receptor expression was significant, with rat fibroblasts expressing 43,000 +/- 15,000 receptors per cell, whereas rabbit and human fibroblasts expressed few receptors.
Why the study?
Are there species differences in angiotensin II receptor expression and function in cardiac fibroblasts?
Population
Cultured cardiac fibroblasts from rats, rabbits, and neonate humans; in situ rat and rabbit hearts subjected…
Comparison
Angiotensin II exposure and coronary artery… vs Across species and noninfarcted tissue
Design
Preclinical
Follow-up
6 days (in situ model)
Authors
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Rat models may overestimate human cardiac fibroblast angiotensin II responses; leaves open species-specific validation in fibrosis research.
Are there species differences in angiotensin II receptor expression and function in cardiac fibroblasts?
Significant species differences in cardiac fibroblast angiotensin II receptor expression suggest that rat models may not accurately reflect human cardiac fibroblast responses to angiotensin.
Gallagher et al. (1998) studied Myocardial infarction. Species (Rat vs Rabbit vs Human) was evaluated on ANG II receptor expression. Species variability in ANG II receptor expression was significant, with rat fibroblasts expressing 43,000 +/- 15,000 receptors per cell, whereas rabbit and human fibroblasts expressed few receptors.
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