Population
Cardiac fibroblasts
Comparison
Tumor necrosis factor-alpha (TNF-alpha) incubation vs Control (untreated)
Design
Preclinical
Follow-up
up to 48 hours
Authors
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May guide preclinical remodeling studies; leaves open human translation of TNF-alpha–AT1 effects.
TNF-alpha upregulates AT1 receptors on cardiac fibroblasts, providing a potential mechanism for its role in post-myocardial infarction remodeling.
Gurantz et al. (1999) studied this question.
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