Key result
In cultured neonatal rat cardiac fibroblasts, TNF-alpha-induced AT1 receptor upregulation enhanced Ang II-stimulated [3H]proline incorporation and TIMP-1 production by approximately 2-fold.
Why the study?
Does TNF-alpha-induced AT1 receptor upregulation alter fibroblast responsiveness to Ang II in cultured neonatal rat cardiac fibroblasts?
Population
Cultured neonatal rat cardiac fibroblasts
Comparison
TNF-alpha pretreatment followed by Angiotensin… vs Nonpretreated fibroblasts
Design
Preclinical
Authors
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May promote post-MI fibroblast fibrosis; leaves open in vivo relevance and therapeutic targeting.
Does TNF-alpha-induced AT1 receptor upregulation alter fibroblast responsiveness to Ang II in cultured neonatal rat cardiac fibroblasts?
Effect estimate: ~2-fold greater
TNF-alpha-induced AT1 receptor upregulation enhances Ang II-mediated functions that favor fibrosis in cardiac fibroblasts, providing insights into post-MI ECM remodeling.
Peng et al. (2002) studied Myocardial infarction (in vitro model). TNF-alpha pretreatment and Angiotensin II vs. Nonpretreated fibroblasts was evaluated on Ang II-stimulated [3H]proline incorporation and TIMP-1 protein production (~2-fold greater). In cultured neonatal rat cardiac fibroblasts, TNF-alpha-induced AT1 receptor upregulation enhanced Ang II-stimulated [3H]proline incorporation and TIMP-1 production by approximately 2-fold.
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