Why the study?
The impact of race, environmental stress, and cortisol on subclinical cardiovascular disease had not been fully researched in children.
Are race and cortisol levels associated with subclinical cardiovascular disease markers in 9- to 11-year-old children?
Population
271 children aged 9 to 11 years (57% Black, 43% White)
Comparison
Black children vs White children
Design
Cross-sectional study
Key result
Black race was associated with flatter diurnal cortisol slopes and higher hair cortisol compared to White race, which in turn were linked to greater subclinical CVD (cfPWV indirect effect -0.059).
Authors
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Race-cortisol links to subclinical CVD in children support hypothesis generation; longitudinal studies needed before any clinical consideration.
Cross-Sectional (n=271)
Are race and cortisol levels associated with subclinical cardiovascular disease markers in 9- to 11-year-old children?
Effect estimate: effect -0.059 (95% CI -0.116, -0.002)
In children aged 9-11 years, Black race is associated with altered cortisol profiles (greater hair cortisol and flatter diurnal slopes), which in turn correlate with greater subclinical cardiovascular disease markers such as cIMT and cfPWV.
Gump et al. (2023) conducted a cross-sectional in Subclinical cardiovascular disease (n=271). Black race vs. White race was evaluated on Carotid-femoral pulse wave velocity (cfPWV) and carotid intima-media thickness (cIMT) (effect -0.059, 95% CI -0.116, -0.002). Black race was associated with flatter diurnal cortisol slopes and higher hair cortisol compared to White race, which in turn were linked to greater subclinical CVD (cfPWV indirect effect -0.059).
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