Key result
HCV 3' noncoding region and core protein stimulated IRES efficiency, with NS5B showing a dose-dependent biphasic effect, suggesting sequential regulation of translation and replication.
Population
Cell-based RNA reporter system for Hepatitis C virus (HCV)
Design
Preclinical
Authors
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Hypothesis-generating for HCV antivirals; leaves open human validation before any therapeutic consideration.
HCV RNA translation is regulated by a sequential requirement for both cis and trans viral factors, suggesting a mechanism for the switch from translation to replication.
Lourenço et al. (2008) studied Hepatitis C virus. cis and trans viral factors (HCV 3' NCR, core protein, NS5B) was evaluated on HCV IRES activity/efficiency. HCV 3' noncoding region and core protein stimulated IRES efficiency, with NS5B showing a dose-dependent biphasic effect, suggesting sequential regulation of translation and replication.
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