Key result
HCV core protein interacts specifically with the positive-sense viral genomic RNA at the 5' untranslated region and suppresses its cap-independent translation in a dose-dependent manner.
Population
In vivo system examining hepatitis C virus (HCV) core protein and its genomic RNA synthesized in vitro
Comparison
Expression of HCV core protein vs Expression of E1 envelope protein of HCV or…
Design
Preclinical
Authors
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HCV core binds 5' RNA in vitro; leaves open roles in morphogenesis and replication targets.
HCV core protein interacts with a specific region of viral genomic RNA to form nucleocapsids and regulates HCV expression by interacting with the 5'UTR.
Shimoike et al. (1999) studied Hepatitis C virus (HCV) infection. HCV core protein expression vs. Control proteins (E1 envelope protein, beta-galactosidase) or EMCV IRES was evaluated on Interaction with viral RNA and suppression of translation. HCV core protein interacts specifically with the positive-sense viral genomic RNA at the 5' untranslated region and suppresses its cap-independent translation in a dose-dependent manner.
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