Key result
Hepatitis C virus core protein specifically interacts with heterogeneous nuclear ribonucleoprotein K (hnRNP K) and relieves its suppression effect on the human thymidine kinase gene promoter.
Population
Human liver cDNA library and in vitro/in vivo models for protein interaction
Design
Preclinical
Authors
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May inform HCV pathogenesis mechanisms; leaves open clinical relevance pending human validation.
The specific binding of HCV core protein to hnRNP K suggests a mechanism by which HCV disrupts cellular functions, contributing to viral pathogenesis.
Hsieh et al. (1998) studied Hepatitis C virus infection. Hepatitis C virus core protein was evaluated on Interaction between HCV core protein and hnRNP K. Hepatitis C virus core protein specifically interacts with heterogeneous nuclear ribonucleoprotein K (hnRNP K) and relieves its suppression effect on the human thymidine kinase gene promoter.
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