Population
Human embryonic kidney 293T cells, human hepatoblastoma HepG2 cells, and Escherichia coli BL21 cells
Comparison
Heterologously expressed fusion proteins… vs Wild-type HCV core protein, GFP alone, or GST…
Design
Preclinical
Authors
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May inform HCV core-targeted antivirals; leaves open clinical relevance pending human validation.
The HCV core protein utilizes specific amino acid motifs for localization to the ER, mitochondria, and nucleus, which may regulate its diverse biological roles.
Suzuki et al. (2004) studied this question.
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