Population
HCV replicon cells and transiently transfected human liver cells expressing HCV nonstructural proteins
Comparison
Expression of HCV nonstructural proteins and… vs Control cells or untreated cells
Design
Preclinical
Authors
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Preclinical HCV replicon data should not change practice; leaves open whether NS proteins drive IRES activity in vivo.
HCV nonstructural proteins preferentially stimulate viral cap-independent, IRES-mediated translation, providing insight into HCV replication mechanisms.
He et al. (2003) studied this question.
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