Key result
The HCV NS5A protein inhibited HCV IRES-dependent translation in a dose-dependent manner, with a 120 amino acid region upstream of the nuclear localization signal being critical for suppression.
Population
Three different cell lines co-transfected with a plasmid vector containing a bicistronic transcript carrying…
Design
Preclinical
Authors
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Hypothesis-generating for NS5A autoregulation of HCV translation; leaves open antiviral implications pending human studies.
The HCV NS5A protein specifically downregulates HCV IRES-dependent translation, suggesting a regulatory role in viral protein synthesis.
Kalliampakou et al. (2005) studied Hepatitis C virus (HCV). HCV NS5A protein was evaluated on HCV IRES-dependent translation. The HCV NS5A protein inhibited HCV IRES-dependent translation in a dose-dependent manner, with a 120 amino acid region upstream of the nuclear localization signal being critical for suppression.
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