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December 13, 2001Journal of Medical Virology

Hepatitis C virus NS4A and NS4B proteins suppress translation in vivo

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Population

HeLa cells and reporter assay systems

Design

Preclinical

Authors

JKJun KatoChiba UniversityNKNaoya KatoChiba UniversityHYHideo YoshidaJapanese Red Cross Medical Center

Discussion

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Implication

NS4A/NS4B-mediated translation suppression may aid HCV survival; leaves open clinical relevance and therapeutic targeting in human infection.

Structured PICO

P
Population
HeLa cells and reporter assay systems
I
Intervention
Expression of seven HCV proteins (core, NS2, NS3, NS4A, NS4B, NS5A, NS5B)
O
Outcome
Influence on cellular protein synthesis

HCV NS4A and NS4B proteins suppress host cell translation, a novel function that may facilitate viral survival during infection.

Cite This Study

Kato et al. (2001) studied this question.

synapsesocial.com/papers/6a86640ab81bbc5ca863a008https://doi.org/10.1002/jmv.2129
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1RNA-protein interactions in regulation of picornavirus RNA translation.1996 · 79 citations
  2. 2Human immunodeficiency virus type 1 Rev is required in vivo for binding of poly(A)-binding protein to Rev-dependent RNAs1994 · 30 citations
  3. 3Isolation of a cDNA cLone Derived from a Blood-Borne Non-A, Non-B Viral Hepatitis Genome1989 · 6,910 citations
  4. 4Translation efficiencies of the 5' untranslated region from representatives of the six major genotypes of hepatitis C virus using a novel bicistronic reporter assay system.1998 · 74 citations
  5. 5Internal ribosome entry site within hepatitis C virus RNA1992 · 925 citations