Population
In vitro cell-free protein synthesis system using lysates from HeLa S3 cells or rabbit reticulocytes and HCV…
Comparison
Capped and uncapped HCV RNAs, artificial mono… vs Capped unmethylated RNA vs capped methylated…
Design
Preclinical
Authors
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Hypothesis-generating for HCV IRES efficiency in animal models; human studies required before clinical relevance.
This study identifies the internal ribosome entry site (IRES) in the 5' untranslated region of HCV RNA, which is crucial for its translation initiation.
Tsukiyama–Kohara et al. (1992) studied this question.
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