Key result
The stem sequences of the alpha-branch region and a novel 25-kDa cellular protein that binds the 5' noncoding region play a critical role in the efficient internal initiation of HCV RNA translation.
Population
In vitro translation system and HeLa cell proteins interacting with hepatitis C virus (HCV) RNA
Design
Preclinical
Authors
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Alpha-branch of HCV IRES may be critical for translation; leaves open in vivo role and antiviral targeting.
The stem sequences of the HCV IRES alpha-branch and a novel 25-kDa cellular protein are critical for efficient internal initiation of HCV RNA translation.
Fukushi et al. (1997) studied Hepatitis C virus (HCV) translation. Sequence exchange within the alpha-branch of HCV IRES and a 25-kDa cellular protein was evaluated on Efficiency of translation initiation of HCV RNA. The stem sequences of the alpha-branch region and a novel 25-kDa cellular protein that binds the 5' noncoding region play a critical role in the efficient internal initiation of HCV RNA translation.
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