Population
In vitro translation systems and liver-derived cells
Comparison
Point mutations and insertional mutagenesis in… vs Wild-type HCV RNA
Design
Preclinical
Authors
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May guide HCV antiviral design; leaves open clinical translation from animal models.
Unlike picornaviruses, the pyrimidine-rich tract motif is not a functional component of the HCV IRES; instead, a helical structural element and proper spacing are essential for internal initiation of translation.
Wang et al. (1994) studied this question.
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