Population
Hepatitis C virus (HCV) RNA (5'NTR) and related flaviviral sequences (in vivo and in vitro models)
Comparison
Mutational analysis of putative helical structures vs Wild-type/unmutated sequences
Design
Preclinical
Authors
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Highlights potential IRES structural targets for antivirals; leaves open clinical translation pending human validation.
A conserved stem-loop structure at the 5' border of the HCV IRES is required for cap-independent viral translation.
Honda et al. (1999) studied this question.
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