Population
Hepatitis C virus (HCV) internal ribosome entry site (IRES) RNA in solution
Design
Preclinical
Authors
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May inform HCV antiviral design targeting IRES folding; leaves open in vivo validation and clinical translation.
The HCV IRES RNA adopts a prefolded tertiary structure dependent on magnesium that spatially organizes recognition domains for the 40S ribosomal subunit and eIF3.
Kieft et al. (1999) studied this question.
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