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February 1, 2001RNAOpen Access

Mechanism of ribosome recruitment by hepatitis C IRES RNA

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Authors

JKJeffrey S. KieftNew York Structural Biology Center KZKaihong ZhouQB3 RJRonald JubinProlong Pharmaceuticals (United States)

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Implication

Hypothesis-generating for IRES-targeted HCV antivirals; leaves open clinical translation pending further studies.

Key Points

Key points are not available for this paper at this time.

Cite This Study

Kieft et al. (2001) studied this question.

synapsesocial.com/papers/6a7d9d3eea910b51ed1869f9 https://doi.org/10.1017/s1355838201001790

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Canonical Eukaryotic Initiation Factors Determine Initiation of Translation by Internal Ribosomal Entry1996 · 500 citations
2Influence of correct secondary and tertiary RNA folding on the binding of cellular factors to the HCV IRES2000 · 59 citations
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4An Enzymatic Footprinting Analysis of the Interaction of 40S Ribosomal Subunits with the Internal Ribosomal Entry Site of Hepatitis C Virus2000 · 160 citations
5Specific Interaction of Eukaryotic Translation Initiation Factor 3 with the 5′ Nontranslated Regions of Hepatitis C Virus and Classical Swine Fever Virus RNAs1998 · 294 citations