Population
In vitro and in vivo models studying the hepatitis C virus (HCV) internal ribosome entry site (IRES)
Comparison
Mutagenesis of the GGG triplet of stem loop IIId… vs Wild-type HCV IRES
Design
Preclinical
Authors
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May nominate HCV IRES stem-loop IIId for antiviral targeting; leaves open translation to human efficacy.
The GGG triplet in stem loop IIId of the HCV IRES is essential for its translational activity and correct RNA folding, presenting a potential target for antiviral therapies.
Jubin et al. (2000) studied this question.
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