Key result
In vitro evaluation of the HCV IRES revealed specific long-range RNA-RNA interactions between domains II and IV, and domains II and IIIabcd, which required magnesium ions.
Long-range RNA-RNA interactions between distant regions of the HCV IRES element may have a regulatory role in translation efficiency.
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These IRES interactions may modulate HCV translation; leaves open therapeutic targeting pending cellular and in vivo validation.
Lafuente et al. (2002) studied Hepatitis C virus (HCV). In vitro RNA transcripts of HCV IRES domains was evaluated on Formation of RNA-RNA complexes. In vitro evaluation of the HCV IRES revealed specific long-range RNA-RNA interactions between domains II and IV, and domains II and IIIabcd, which required magnesium ions.
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