August 1, 2002RNAOpen Access

Domains on the hepatitis C virus internal ribosome entry site for 40s subunit binding

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Population

Hepatitis C virus (HCV) internal ribosome entry site (IRES) RNA and 40S ribosomal subunits

Design

Preclinical

Authors

JLJessica LytleHoward Hughes Medical Institute LWLily WuAPLA Health HRHugh D. RobertsonThe Honourable Society of Lincoln's Inn

Discussion

Member takes

Implication

Preliminary HCV IRES data; leaves open stem-loop II as antiviral target pending human validation.

Structured PICO

Population

Hepatitis C virus (HCV) internal ribosome entry site (IRES) RNA and 40S ribosomal subunits

Intervention

Direct analysis of RNase-protected HCV IRES domains bound to 40S ribosomal subunits

Outcome

Identification of domains involved in the initial binding step to 40S ribosomal subunitssurrogate

The study reveals that stem-loop II of the HCV IRES is involved in the initial binding to the 40S ribosomal subunit, indicating its role in the first step of translation initiation.

Cite This Study

Lytle et al. (2002) studied this question.

synapsesocial.com/papers/6a10cc7aba20d9a181ee4f06 https://doi.org/10.1017/s1355838202029965

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Bookmark

Domains on the hepatitis C virus internal ribosome entry site for 40s subunit binding

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Domains on the hepatitis C virus internal ribosome entry site for 40s subunit binding

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider