Population
Hepatitis C virus internal ribosomal entry site (IRES) and 40S ribosomal subunits
Design
Preclinical
Authors
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Pinpoints HCV IRES-40S contacts in animal models; extends mechanistic maps but leaves open human validation and antiviral targeting.
The 40S ribosomal subunit makes multiple specific interactions with the HCV IRES, with domain IV likely inserted into the mRNA-binding cleft.
Kolupaeva et al. (2000) studied this question.
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