Key result
HCV IRES subdomain IIId cross-links to ribosomal proteins S3a, S14, and S16, and the apex of domain II cross-links to proteins S14 and S16 on the human 40S ribosome.
Population
Human 40S ribosome and hepatitis C virus (HCV) IRES RNA
Design
Preclinical
Authors
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Maps HCV IRES-ribosome contacts; extends structural models but leaves open functional and therapeutic validation.
The study identifies specific ribosomal proteins (S3a, S14, S16) that interact with critical domains of the HCV IRES, providing structural insights into viral translation initiation.
Babaylova et al. (2008) studied Hepatitis C. Site-directed cross-linking was evaluated on Identification of 40S subunit components neighboring subdomain IIId and apical loop of domain II. HCV IRES subdomain IIId cross-links to ribosomal proteins S3a, S14, and S16, and the apex of domain II cross-links to proteins S14 and S16 on the human 40S ribosome.