Key result
The Framingham risk score severely underestimated cardiovascular risk in an Indian population, classifying only 4.8% of patients who developed a first acute coronary syndrome as high risk and 63.8% as low risk.
Why the study?
Evidence questions the predictive ability of the Framingham risk score for cardiovascular disease risk stratification in ethnic Indian and Asian populations.
Population
Patients with first-time acute myocardial infarction at a single institution
Comparison
Risk stratification by Framingham risk score (FRS-CHD 2002)
Design
Single-institutional retrospective observational study
Authors
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Caution advised applying Framingham score to Indian patients; hypothesis-generating for ethnicity-specific recalibration in prospective studies.
Observational (n=105)
No
The Framingham risk score significantly underestimates the risk of acute coronary syndrome in the Indian population, classifying the vast majority of patients who subsequently develop ACS as low risk.
Das et al. (2022) conducted an observational in First acute coronary syndrome (ACS) (n=105). Framingham risk score (FRS) was evaluated on Classification into the high-risk category for cardiovascular disease by the Framingham risk score prior to the acute coronary syndrome event. The Framingham risk score severely underestimated cardiovascular risk in an Indian population, classifying only 4.8% of patients who developed a first acute coronary syndrome as high risk and 63.8% as low risk.