Key points are not available for this paper at this time.
Thyroid hormone exerts a broad range of effects on development, growth, and metabolism. The clinical manifestations of thyroid hormone excess and deficiency are dramatic examples of the myriad actions of the hormone. Thyroxine (T4), the primary secretory product of the thyroid, is relatively inactive and is converted to the active hormone, triiodothyronine (T3), by the enzyme thyroxine 5'-deiodinase (Figure 1)1. The actions of thyroid hormone are primarily the result of the interaction of T3 with nuclear receptors for T3 that bind to regulatory regions of genes (thyroid hormone-response elements) and modify their expression . . .
Epstein et al. (Thu,) studied this question.