Deprotonation of epoxides followed by trapping with electrophiles was carried out using microflow systems with varying temperature and residence time. Time-dependence of the yields of products provides a deeper insight into chemical and configurational stabilities of oxiranyllithiums. With the thus-obtained information, reactions of oxiranyllithiums with various electrophiles were successfully carried out without decomposition and isomerization.
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Nagaki et al. (2009) studied this question.
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