Key result
Scheduled intravenous metoclopramide induced serotonin syndrome in a 28-year-old woman being treated for acetaminophen toxicity.
Why the study?
Serotonin syndrome carries high morbidity and mortality requiring a high index of suspicion, and metoclopramide very rarely causes this condition by itself.
Can intravenous metoclopramide cause serotonin syndrome in a patient with acetaminophen toxicity?
Case Report (n=1)
No
Can intravenous metoclopramide cause serotonin syndrome in a patient with acetaminophen toxicity?
Metoclopramide can rarely cause serotonin syndrome, highlighting the need for a high index of suspicion when using this agent.
Serotonin syndrome is a clinical diagnosis characterized by a constellation of autonomic and neurological physical examination findings due to the use of one or more serotonergic agents. Due to high morbidity and mortality associated with this condition, high index of suspicion is required in making this diagnosis. Treatment is aimed at discontinuation of the offending agent and supportive care. We present a case of a 28-year-old woman who presented with acetaminophen toxicity, however developed iatrogenic serotonin syndrome due to use of scheduled intravenous metoclopramide. Metoclopramide, by itself, very rarely causes serotonin syndrome and typically results in this condition when used in combination with other pro-serotonergic agents.
No takes yet. Share an insight, caveat, or question.
Meegada et al. (2019) conducted a case report in Serotonin syndrome (n=1). Metoclopramide was evaluated on Development of serotonin syndrome. Scheduled intravenous metoclopramide induced serotonin syndrome in a 28-year-old woman being treated for acetaminophen toxicity.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: