Key result
Reviewed medical therapies show no benefit in inhibiting abdominal aortic aneurysm dilation.
Why the study?
The development of medical therapies that limit or prevent the progression, expansion, and eventual rupture of abdominal aortic aneurysms remains an unmet clinical need.
Do various drug classes prevent the dilation of abdominal aortic aneurysm in patients with abdominal aortic aneurysm?
Do various drug classes prevent the dilation of abdominal aortic aneurysm in patients with abdominal aortic aneurysm?
Current evidence does not support the use of any specific medical therapy to effectively inhibit the progression of abdominal aortic aneurysms.
No medical therapy can be recommended to slow abdominal aortic aneurysm growth; leaves open whether novel agents merit randomized evaluation.
INTRODUCTION: Abdominal aortic aneurysm is a progressive, segmental, abdominal aortic dilation associated with a high mortality rate. Abdominal aortic aneurysms with diameters larger than 55 mm are associated with a high risk of rupture, and the most effective treatment options are surgical repair. Close observation and lifestyle adjustments are recommended for smaller abdominal aortic aneurysms with lower rupture risk. The development of medical therapies that limit or prevent the progression, expansion, and eventual rupture of abdominal aortic aneurysms remains an unmet clinical need. AREAS COVERED: This review provides an overview of completed and ongoing clinical trials examining the efficacies of various drug classes, including antibiotics, antihypertensive drugs, hypolipidemic drugs, hypoglycemic drugs, and other potential therapies for abdominal aortic aneurysms. A search of PubMed, Web of Science, Clinical Trials, and another six clinical trial registries was conducted in January 2024. EXPERT OPINION: None of the drugs have enough evidence to indicate that they can effectively inhibit the dilation of abdominal aortic aneurysm. More clinical trial data is required to support the efficacy of propranolol. Future research should also explore different drug delivery mechanisms, such as nanoparticles, to elevate drug concentration at the aneurysm wall.
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Chen et al. (2024) conducted a review in Abdominal aortic aneurysm. Medical treatments (antibiotics, antihypertensive drugs, hypolipidemic drugs, hypoglycemic drugs) was evaluated on Dilation of abdominal aortic aneurysm. None of the reviewed medical therapies have sufficient evidence to indicate that they can effectively inhibit the dilation of abdominal aortic aneurysms.
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