Key result
Differentiation of monocytes to macrophages increased cellular angiotensin converting enzyme activity 3.2-fold and angiotensin II production 4.5-fold.
Population
Human leukemia cell line, THP-1, used as a model for monocytes and differentiated into macrophages using…
Comparison
Differentiation into macrophages and incubation… vs Undifferentiated THP-1 monocytes.
Design
Preclinical
Authors
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Macrophage RAS activation may promote atherosclerosis; leaves open human relevance and therapeutic implications.
Effect estimate: 3.2- and 4.5-fold increase
The renin-angiotensin system is markedly activated during monocyte-to-macrophage differentiation, suggesting a cellular mechanism contributing to the development of atherosclerosis.
Okamura et al. (1999) studied Atherosclerosis. Differentiation of monocytes to macrophages vs. Undifferentiated monocytes was evaluated on Expression of renin-angiotensin system components (ACE activity and angiotensin II production) (3.2- and 4.5-fold increase). Differentiation of monocytes to macrophages increased cellular angiotensin converting enzyme activity 3.2-fold and angiotensin II production 4.5-fold.
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