Key result
In 11 anaesthetised dogs, wave speeds determined by the PU-loop in the aortic root were systematically lower than those measured by the foot-to-foot method.
Why the study?
Does the pressure-velocity loop (PU-loop) method accurately measure arterial wave speed compared to the foot-to-foot method, and how does arterial occlusion affect these measurements in an animal model?
Population
11 anaesthetised dogs
Comparison
Total arterial occlusion lasting 3 min produced… vs Control conditions
Design
Preclinical
Authors
Loading...
PU-loop yields lower aortic wave speeds than foot-to-foot in dogs; leaves open validation and clinical interchangeability in humans.
Does the pressure-velocity loop (PU-loop) method accurately measure arterial wave speed compared to the foot-to-foot method, and how does arterial occlusion affect these measurements in an animal model?
The PU-loop method is an objective and easy-to-use alternative for determining local arterial wave speed, particularly advantageous in short arterial segments.
Khir et al. (2003) studied Anaesthetised dogs (animal model) (n=11). Arterial occlusion and PU-loop method vs. Control conditions and foot-to-foot method was evaluated on Arterial wave speed. In 11 anaesthetised dogs, wave speeds determined by the PU-loop in the aortic root were systematically lower than those measured by the foot-to-foot method.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: