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The study investigates if the loss of the L-selectin-low phenotype in CD8+ T cells is a permanent feature of long-term memory cells.

Temporal loss of the activated L-selectin-low phenotype for virus-specific CD8+ memory T cells.

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The study investigates if the loss of the L-selectin-low phenotype in CD8+ T cells is a permanent feature of long-term memory cells.
Mice were primed with influenza A virus or Sendai virus to assess CD8+ T cell phenotype.
Analysis of splenic CD8+ T cell populations focused on L-selectin and alpha 4-integrin expression over time.
In vitro restimulation was conducted to evaluate reversion to L-selectin-low phenotype.
CD8+ memory T cells gradually lost the L-selectin-low phenotype over time.
Influenza-specific T cells reverted from alpha 4-integrin-high to alpha 4-integrin-low with distinct kinetics for each virus.
The total pool of L-selectin-low CD8+ T cells increased with age despite the phenotype switch.

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Randomized trial examines changes in memory T cell phenotype in mice following viral infection, indicating dynamic immune responses.

Tripp et al. (1995) studied this question.

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