Key result
Digoxin induced slowly developing, long-lasting contractions in isolated human crural vessels that were dependent on extracellular calcium and potentiated responses to noradrenaline and potassium.
Why the study?
Does digoxin induce contractile effects in isolated human peripheral arteries and veins?
Population
Isolated human crural arteries and veins
Comparison
Digoxin (including pretreatment with 1 μM) vs Control conditions
Design
Preclinical
Authors
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May warrant caution in vascular reactivity studies; leaves open in vivo relevance for digoxin in peripheral arteries.
Does digoxin induce contractile effects in isolated human peripheral arteries and veins?
Digoxin has a direct, calcium-dependent contractile effect on human peripheral vessels and alters their reactivity to noradrenaline and potassium.
Mikkelsen et al. (1979) studied Isolated human crural arteries and veins. Digoxin was evaluated on Contractile responses. Digoxin induced slowly developing, long-lasting contractions in isolated human crural vessels that were dependent on extracellular calcium and potentiated responses to noradrenaline and potassium.
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