The application of tissue engineering technology to wound healing has resulted in the development of a number of "living skin equivalents." These have become a viable option in the treatment of chronic, nonhealing wounds. Such wounds present a major cost burden as well as increased morbidity and mortality. Unique among skin tissue engineering technology is the TissueTech autograft system, as it incorporates an autologous dermal substitute-Hyalograft 3D-and an autologous epidermal replacement, Laserskin autograft. Each includes a matrix of a hyaluronic acid ester to promote cellular migration and graft take.
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Luigi Uccioli (2003) studied this question.
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