Key result
This review discusses the molecular pathology, immunopathophysiology, and genetic basis of multiple sclerosis, highlighting the role of autoreactive T cells and new therapeutic approaches.
High-throughput molecular techniques offer new avenues for understanding the pathology of multiple sclerosis and developing targeted therapies.
May guide T-cell targeted MS therapies; leaves open validation in prospective trials.
Multiple sclerosis is a complex genetic disease associated with inflammation in the CNS white matter thought to be mediated by autoreactive T cells. Clonal expansion of B cells, their antibody products, and T cells, hallmarks of inflammation in the CNS, are found in MS. This review discusses new methods to define the molecular pathology of human disease with high-throughput examination of germline DNA haplotypes, RNA expression, and protein structures that will allow the generation of a new series of hypotheses that can be tested to develop better understanding of and therapies for this disease.
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David A. Hafler (2004) conducted a review in Multiple sclerosis. This review discusses the molecular pathology, immunopathophysiology, and genetic basis of multiple sclerosis, highlighting the role of autoreactive T cells and new therapeutic approaches.
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