Key result
Adult spontaneously hypertensive rats had 30% to 35% fewer 25-35 mu intestinal arterioles and 20% to 25% constriction of the largest and smallest arterioles compared to normal WKY rats.
Authors
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Suggests arteriolar rarefaction may sustain hypertension in this model; leaves open human relevance and need for clinical studies.
H. Glenn Bohlen (1983) studied Hypertension. Spontaneous hypertension (SHR strain) vs. Normal Wistar-Kyoto (WKY) rats was evaluated on Intestinal microvascular adaptation (number and diameter of arterioles). Adult spontaneously hypertensive rats had 30% to 35% fewer 25-35 mu intestinal arterioles and 20% to 25% constriction of the largest and smallest arterioles compared to normal WKY rats.
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