Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 17, 2023Annals of MedicineOpen Access

Life’s Essential 8 is associated with atherosclerotic cardiovascular disease but not venous thromboembolism in men: a prospective cohort study

View Full Paper
Ask AI
Bookmark
Share

Key result

Highest Life's Essential 8 score linked to ~58% lower ASCVD risk, but not VTE.

  • HR 0.42
  • 95% CI 0.34-0.51
  • n=1,899

Why the study?

ASCVD and VTE share risk factors, and the AHA Life's Simple 7 score was recently upgraded to Life's Essential 8 (LE8), prompting investigation of its prospective association with both conditions.

Does a higher Life's Essential 8 score reduce the risk of ASCVD and VTE in middle-aged men?

Population

1899 men aged 42–61 years in Finland

Comparison

Quartiles of Life's Essential 8 score (Q1 to Q4)

Design

Prospective cohort study

Follow-up

Median 24 and 25 years

Authors

NINzechukwu M. IsiozorUniversity of Eastern FinlandJLJari A. LaukkanenPreventive CardiologyAVAri VoutilainenGeneral / Preventive / Lipids

Discussion

Loading...

Member takes

Overview

Higher LE8 adherence may aid ASCVD prevention in middle-aged men; leaves open VTE effects and needs randomized confirmation.

Study Design

Type

Cohort (n=1,899)

Structured PICO

Does a higher Life's Essential 8 score reduce the risk of ASCVD and VTE in middle-aged men?

P
Population
1,899 Finnish men aged 42-61 years followed for a median of 24 to 25 years to assess the association of the Life's Essential 8 score with ASCVD and VTE.
E
Exposure
High Life's Essential 8 (LE8) score (Quartile 4: >550, based on physical activity, diet, nicotine exposure, sleep health, BMI, blood lipids, blood glucose, and blood pressure)
C
Comparator
Low Life's Essential 8 (LE8) score (Quartile 1: ≤ 420)
O
Outcome
Incident atherosclerotic cardiovascular disease (ASCVD) and venous thromboembolism (VTE)hard clinical

Main Result

Hazard Ratio: 0.42 (95% CI 0.34–0.51)

High adherence to the AHA's Life's Essential 8 metrics is strongly associated with long-term prevention of ASCVD, but not VTE, in middle-aged men.

Limitations

  • Study population limited to middle-aged and older Finnish men, lacking women and other population groups
  • Study limited to middle-aged and older Finnish men, requiring further studies in women and other population groups

Cite This Study

Isiozor et al. (2023) conducted a cohort in Atherosclerotic cardiovascular disease and venous thromboembolism (n=1,899). High Life's Essential 8 (LE8) score (Quartile 4) vs. Lowest LE8 quartile (Quartile 1) was evaluated on Atherosclerotic cardiovascular disease (ASCVD) (HR 0.42, 95% CI 0.34-0.51). The highest quartile of the Life's Essential 8 score was associated with a lower risk of ASCVD (HR 0.42; 95% CI 0.34-0.51) but not VTE (HR 1.02; 95% CI 0.60-1.74) compared to the lowest quartile.

synapsesocial.com/papers/6a2025104f3426e554a1bcbfhttps://doi.org/10.1080/07853890.2023.2233894

Topics

Women and heart disease
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1American Heart Association's Life's Simple 7 and Risk of Venous Thromboembolism: The Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study2015 · 82 citations
  2. 2Life's Simple 7 and the risk of stroke in Finnish men: A prospective cohort study2021 · 14 citations
  3. 3Association Between Life's Simple 7 and Noncardiovascular Disease: The Multi‐Ethnic Study of Atherosclerosis2016 · 135 citations
  4. 4Life’s Essential 8: Updating and Enhancing the American Heart Association’s Construct of Cardiovascular Health: A Presidential Advisory From the American Heart Association2022 · 2,738 citations
  5. 5Cardiovascular Health Metrics and Risk of Heart Failure in a Finnish Population: A Prospective Cohort Study2023 · 9 citations