What question did this study set out to answer?

This research investigates how different CYP2D6 genotypes influence the plasma concentrations of risperidone and its active metabolite in schizophrenia.

May 27, 2003Therapeutic Drug Monitoring

Effects of Various CYP2D6 Genotypes on the Steady-State Plasma Concentrations of Risperidone and Its Active Metabolite, 9-Hydroxyrisperidone, in Japanese Patients With Schizophrenia

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Authors

KMKazuo MiharaYamagata University TKTsuyoshi KondoUniversity of the Ryukyus NYNorio Yasui‐FurukoriDokkyo Medical University

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Implication

Randomized trial evaluates CYP2D6 genotypes impact on risperidone concentrations in Japanese schizophrenia patients, indicating limited clinical importance.

Key Points

This research investigates how different CYP2D6 genotypes influence the plasma concentrations of risperidone and its active metabolite in schizophrenia.
85 Japanese patients with schizophrenia received 6 mg/d risperidone for at least 2 weeks.
CYP2D6 genotypes were categorized, and plasma concentrations were measured using mass spectrometry.
Css values were corrected for median body weight (58 kg).
CYP2D6 status significantly influences risperidone Css among various genotype groups (P < 0.05 or P < 0.001).
The Css for risperidone varied from 2.2 to 91.8 nmol/L across different genotypes.
No significant differences in Css of 9-hydroxyrisperidone and active moiety among genotype groups.

Cite This Study

Mihara et al. (2003) studied this question.

synapsesocial.com/papers/6a20259d349f479269fbf666 https://doi.org/10.1097/00007691-200306000-00006

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Implication

Randomized trial evaluates CYP2D6 genotypes impact on risperidone concentrations in Japanese schizophrenia patients, indicating limited clinical importance.

Effects of Various CYP2D6 Genotypes on the Steady-State Plasma Concentrations of Risperidone and Its Active Metabolite, 9-Hydroxyrisperidone, in Japanese Patients With Schizophrenia

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Implication

Key Points

Cite This Study

Effects of Various CYP2D6 Genotypes on the Steady-State Plasma Concentrations of Risperidone and Its Active Metabolite, 9-Hydroxyrisperidone, in Japanese Patients With Schizophrenia

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Implication

Key Points

Cite This Study

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