Key result
Transient linear motion in awake rats produced a short-latency increase in mean BP (peak 8.27 +/- 0.66 mmHg) of otolith origin, which was attenuated by inactivation of vestibular nuclei.
Population
Awake rats
Comparison
Pure linear motion (natural otolith stimulation) vs Pentobarbital sodium anesthetized rats…
Design
Preclinical
Authors
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Rodent model links otolith input to acute BP rise; leaves open translation to human vestibular-cardiovascular reflexes.
This study establishes a rodent model demonstrating that natural otolith stimulation via linear acceleration directly mediates cardiovascular responses, specifically short-latency increases in blood pressure.
Zhu et al. (2007) studied this question. Transient linear motion (natural otolith stimulation) vs. Anesthetized, labyrinthectomized, or baroreceptor denervated rats was evaluated on Mean blood pressure (BP) and heart rate (HR) responses. Transient linear motion in awake rats produced a short-latency increase in mean BP (peak 8.27 +/- 0.66 mmHg) of otolith origin, which was attenuated by inactivation of vestibular nuclei.
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