Why the study?
Does the ProC Global assay accurately detect abnormalities of the protein C anticoagulant pathway in patients with a thrombotic history?
Does the ProC Global assay accurately detect abnormalities of the protein C anticoagulant pathway in patients with a thrombotic history?
The ProC Global assay is highly sensitive for detecting factor V Leiden and APC resistance but lacks sensitivity for protein S deficiency and has a high false-positive rate.
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Performance limitations warrant caution against routine clinical use; leaves open utility in thrombophilia screening pending prospective validation.
Toulon et al. (2000) studied this question.
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