Key result
Modulation of iron, oxygen, and superoxide may dictate whether nitric oxide is hepatoprotective or hepatotoxic during inflammatory stress.
Population
Hepatocytes (in vivo, in vitro, and in silico models)
Design
Preclinical
Authors
Loading...
Caution against nitric oxide modulation in inflammatory liver injury; hypothesis-generating for redox-targeted therapies in humans.
The magnitude of redox stress, modulated by iron, oxygen, and superoxide, determines whether nitric oxide protects against or induces hepatocyte apoptosis.
Vodovotz et al. (2004) studied Inflammatory settings such as sepsis and shock. Nitric oxide (NO*) was evaluated on Hepatocyte apoptosis and cell survival. Modulation of iron, oxygen, and superoxide may dictate whether nitric oxide is hepatoprotective or hepatotoxic during inflammatory stress.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: