July 1, 1996Circulation

Correlation of Ischemia-Induced Extracellular and Intracellular Ion Changes to Cell-to-Cell Electrical Uncoupling in Isolated Blood-Perfused Rabbit Hearts

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Population

Isolated blood-perfused rabbit hearts loaded with 5F-BAPTA

Design

Preclinical

Follow-up

30 to 35 minutes

Authors

LOLisa M. OwensNational Institute of Environmental Health Sciences TFTeresa A. FralixNational Institute of Environmental Health Sciences EMElizabeth MurphyCross-Cutting Cardiology

Discussion

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Implication

Should not change clinical ischemia management; leaves open whether rabbit uncoupling thresholds translate to human arrhythmias.

Structured PICO

Population

Isolated blood-perfused rabbit hearts loaded with 5F-BAPTA

Intervention

30 to 35 minutes of no-flow ischemia

Outcome

Relationship between changes in phosphocreatine (PCr), adenosine triphosphate (ATP), intracellular calcium ([Ca2+]i), intracellular pH (pHi), extracellular potassium ([K+]e), extracellular pH (pHe), and whole-tissue resistance (rt)surrogate

In an isolated rabbit heart model, ischemia-induced cellular electrical uncoupling is temporally linked to severe intracellular acidosis and calcium overload, which can be tracked by extracellular potassium changes.

Cite This Study

Owens et al. (1996) studied this question.

synapsesocial.com/papers/6a755d4bcc7f6f86c7033316 https://doi.org/10.1161/01.cir.94.1.10

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Correlation of Ischemia-Induced Extracellular and Intracellular Ion Changes to Cell-to-Cell Electrical Uncoupling in Isolated Blood-Perfused Rabbit Hearts

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Correlation of Ischemia-Induced Extracellular and Intracellular Ion Changes to Cell-to-Cell Electrical Uncoupling in Isolated Blood-Perfused Rabbit Hearts

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider