Key result
Reperfusion of rabbit papillary muscles 10 minutes after ischemia-induced electrical uncoupling resulted in reversible uncoupling and restoration of conduction in 14 muscles with complete reflow.
Population
25 reperfused rabbit papillary muscles
Comparison
Reperfusion 10 minutes after the onset of… vs No-flow ischemia
Design
Preclinical
Authors
Loading...
Reperfusion may restore conduction without irreversible injury in vitro; leaves open translation to human ischemia-reperfusion.
Cell-to-cell electrical uncoupling during ischemia is largely reversible upon complete reperfusion and does not indicate irreversible injury in rabbit papillary muscles.
Cascio et al. (2001) studied Ischemia and reperfusion (n=25). Reperfusion vs. Ischemia (pre-reperfusion) was evaluated on Reversibility of ischemia-induced changes in extracellular K+, resting membrane potential, and electrical coupling. Reperfusion of rabbit papillary muscles 10 minutes after ischemia-induced electrical uncoupling resulted in reversible uncoupling and restoration of conduction in 14 muscles with complete reflow.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: