Key result
Induction of ischemia in rabbit papillary muscles caused an early increase in extracellular resistance followed by rapid electrical uncoupling (threefold increase in intracellular resistance).
Why the study?
Does induction of ischemia alter extracellular and intracellular longitudinal resistances and conduction velocity in isolated rabbit papillary muscles?
Population
Isolated, arterially blood-perfused rabbit papillary muscles
Comparison
Induction of ischemia by exchanging O2 in the… vs Pre-ischemic baseline state
Design
Preclinical
Follow-up
Up to 20 minutes of ischemia
Authors
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May explain early conduction slowing in ischemia; leaves open whether uncoupling drives human arrhythmias.
Does induction of ischemia alter extracellular and intracellular longitudinal resistances and conduction velocity in isolated rabbit papillary muscles?
Early ischemia increases extracellular resistance contributing to conduction slowing, followed by rapid cellular uncoupling that may promote arrhythmias.
Kléber et al. (1987) studied Ischemia. Induction of ischemia (exchanging O2 by N2 and arresting coronary flow) vs. Baseline was evaluated on Extracellular and intracellular longitudinal resistances (ro and ri), transmembrane potentials, and conduction velocity. Induction of ischemia in rabbit papillary muscles caused an early increase in extracellular resistance followed by rapid electrical uncoupling (threefold increase in intracellular resistance).