Key result
During the first 10 minutes of acute ischemia in rabbit hearts, an endocardial border zone of 40 to 60 cell layers exists where transmembrane potentials are relatively unaffected.
Population
Isolated preparations of rabbit interventricular septum
Design
Preclinical
Follow-up
7 to 12 minutes
Authors
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May promote early ischemia-related arrhythmias via subendocardial inhomogeneity; hypothesis-generating in rabbits and requires human confirmation.
During acute ischemia, an electrophysiologic and metabolic border zone exists in the subendocardium, creating inhomogeneity that may contribute to early arrhythmogenesis.
Wilensky et al. (1986) studied Acute ischemia. Acute ischemia (stopping coronary flow) was evaluated on Transmembrane potentials, extracellular K+, pH, and phosphocreatine levels at different depths. During the first 10 minutes of acute ischemia in rabbit hearts, an endocardial border zone of 40 to 60 cell layers exists where transmembrane potentials are relatively unaffected.
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