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April 1, 1982AJP Heart and Circulatory Physiology

Extracellular K+ accumulation during myocardial ischemia in isolated rabbit heart

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Population

Isolated arterially perfused rabbit interventricular septum

Design

Preclinical

Authors

JWJames N. WeissElectrophysiologyKSK. I. ShineUniversity of California, Los Angeles

Discussion

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Implication

May mark onset of irreversible ischemic injury in animal models; leaves open clinical translation for timing cardioprotective therapies.

Structured PICO

P
Population
Isolated arterially perfused rabbit interventricular septum
I
Intervention
Global ischemia
O
Outcome
Extracellular K+ activity ([K+]o) accumulationsurrogate

This preclinical study characterizes the triphasic accumulation of extracellular potassium during myocardial ischemia, linking the late phase to irreversible tissue damage.

Cite This Study

Weiss et al. (1982) studied this question.

synapsesocial.com/papers/6a826b7cfe5ce613f33acfdchttps://doi.org/10.1152/ajpheart.1982.242.4.h619
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1[K+]o accumulation and electrophysiological alterations during early myocardial ischemia1982 · 83 citations
  2. 2Mechanistic investigation of extracellular K<sup>+</sup>accumulation during acute myocardial ischemia: a simulation study2002 · 43 citations
  3. 3Early changes in extracellular potassium in ischemic rabbit myocardium. The role of extracellular carbon dioxide accumulation and diffusion.1992 · 62 citations
  4. 4Contribution of shrinkage of extracellular space to extracellular K+ accumulation in myocardial ischaemia of the rabbit.1996 · 51 citations
  5. 5The subendocardial border zone during acute ischemia of the rabbit heart: an electrophysiologic, metabolic, and morphologic correlative study.1986 · 105 citations