Population
Isolated, blood-perfused rabbit papillary muscle preparation
Comparison
Myocardial ischemia vs Pre-ischemic control or untreated ischemic control
Design
Preclinical
Follow-up
10 minutes
Authors
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Supports K+ efflux targeting for ischemia research; leaves open arrhythmia prevention strategies pending human validation.
Extracellular potassium accumulation during early myocardial ischemia is primarily driven by increased net K+ efflux rather than shrinkage of the extracellular space.
Yan et al. (1996) studied this question.
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