Population
Perfused rabbit hearts submitted to 60 min hypoxia with paced electrical activity (2.5 Hz)
Comparison
Altered external potassium concentration… vs Hypoxia in medium containing 5 mM potassium…
Design
Preclinical
Follow-up
60 minutes
Authors
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Implicates voltage-dependent K channels in hypoxic efflux; leaves open in vivo relevance and clinical translation.
Voltage-dependent channels are implicated in hypoxia-induced potassium loss, which can be modulated by external potassium concentrations.
Leblanc et al. (1987) studied this question.
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