Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 1, 1992Acta Physiologica Scandinavica

Myocardial potassium balance associated with regional ischaemia in the pig: effects of β‐adrenoceptor blockade, duration of ischaemia and preceding ischaemic periods

View Full Paper
Ask AI
Bookmark
Share

Population

12 open-chest pigs

Comparison

Beta-adrenoceptor blockade and consecutive… vs Different durations of ischaemia and…

Design

Preclinical

Authors

GAGunnar AksnesOslo University HospitalKKKnut Arvid KirkebøenOslo University HospitalKLKnut LandeOslo University Hospital

Discussion

Loading...

Member takes

Implication

Escalating K+ losses with ischemia duration in porcine hearts, unaffected by propranolol; hypothesis-generating for Na/K-pump preservation in human stunning.

Structured PICO

P
Population
12 open-chest pigs
I
Intervention
Beta-adrenoceptor blockade (propranolol 1 mg kg-1 i.v.) and consecutive periods of regional ischaemia (2, 2, 5, 10, and 2 min) separated by 30 min of reperfusion
C
Comparator
Different durations of ischaemia and pre-ischaemic baseline
O
Outcome
Ischaemia-induced changes in myocardial K+ balancesurrogate

In a porcine model, prolonged ischaemia progressively stimulated the Na/K-pump, and Na/K-pump function was preserved in stunned myocardium.

Cite This Study

Aksnes et al. (1992) studied this question.

synapsesocial.com/papers/6a8cffde7bbddcec12968086https://doi.org/10.1111/j.1748-1716.1992.tb09334.x
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1<i>In‐vivo</i>quantification of myocardial Na‐K pump rate during β‐adrenergic stimulation of intact pig hearts1989 · 14 citations
  2. 2Isoprenaline augments total myocardial K+influx of thein‐situbeating porcine heart1990 · 3 citations
  3. 3Catecholamine-induced myocardial potassium uptake mediated by beta 1-adrenoceptors and adenylate cyclase activation in the pig.1987 · 24 citations
  4. 4Potassium accumulation in the globally ischemic mammalian heart. A role for the ATP-sensitive potassium channel.1990 · 227 citations
  5. 5Preconditioning of ischemic myocardium: reperfusion-induced arrhythmias1987 · 339 citations