Key result
Pacing tachycardia in pigs induced a transient loss of myocardial potassium (13.0 µmol/100 g) during the first 90 seconds, followed by potassium uptake upon discontinuing pacing.
Population
Pigs with an intact circulation (in situ pig heart)
Comparison
Pacing tachycardia vs Control heart rate (before and after pacing)
Design
Preclinical
Authors
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No immediate clinical implications; leaves open mechanistic links between potassium shifts and tachycardia inotropy for human studies.
In an in situ pig heart model, pacing-induced tachycardia causes a small, transient loss of myocardial potassium, which may be related to the positive inotropic effect of tachycardia.
Ilebekk et al. (1986) studied Pigs with intact circulation. Pacing tachycardia vs. Control values (discontinuing pacing) was evaluated on Myocardial potassium balance (release and uptake). Pacing tachycardia in pigs induced a transient loss of myocardial potassium (13.0 µmol/100 g) during the first 90 seconds, followed by potassium uptake upon discontinuing pacing.
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